Evaluation of Association Between Infection of Endodontic Origin, Their Management and Systemic Health: A Narrative Literature Review

Objective: The most common dental condition is root canal infection. A focal infection a localised or widespread that caused by the systemic spread of microbes their metabolites from one more different foci focus infection, which described as "a restricted area continuously infected with hazardous bacteria," may exist everywhere in body. In literature on medicine and dentistry, tonsils, adenoids, oral tissues, other structures have all been considered potential sites. This review will evaluate current research dynamic relationships between infections endodontic origin, therapy, overall health light new information has since come to light. Methods materials: comprehensive search was conducted for non-grey published using online platforms PubMed, MEDLINE, Scopus, web sciences. To make sure pertinent studies were found, succeeding keywords applied.: “endodontic infections”, “systemic conditions”, “management”, “apical periodontitis”, “diabetes”, “hypertension”. Furthermore, appropriate scientific papers role management diseases included. 18 articles included review. Results: Articles showed advancement progression CVDs linked higher concentrations inflammatory markers individuals periodontitis at apex, according number systematic reviews meta-analyses. Persistent apex influence onset development atherosclerosis through possible mechanisms. provides significant support notion people DM had rates apical periodontitis, larger periapical lesions, than patients without diabetes. Conclusion: There growing evidence prolonged periodontitis-related bacteraemia reduced cytokines deleterious impact health, including CVD development, autoimmune disorders, diabetic metabolic dysregulation. Bangladesh Journal Medical Science Vol.22 (Special Issue) 2023 p.78-88